Wilshere has yet to play for the Gunners in the new Premier League season, having spent the last campaign on loan at Bournemouth.
However, the 25-year-old is now fit again following his recovery from the fracture to his lower left leg suffered during Bournemouth's 4-0 defeat at Tottenham in April.
Wilshere was one of three first-team squad players drafted into Steve Gatting's side, and helped put Arsenal on the way to leading 4-1.
However, just after the hour mark Wilshere reacted to a heavy tackle from City midfielder Matthew Smith and then grappled with Tyreke Wilson, which earned both him and the defender a red card following a scuffle in the centre-circle.
Arsenal went on to win the match 4-3. Afterwards, Wilshere posted a positive message on his Instagram account as he focused on forcing his way back in the first-team picture.
He said: "Well, that was eventful ? felt good to be back on the pitch at the Emirates even though it ended earlier than I thought. My passion and my hunger is back, buzzing for more games ???? #JW10"
The midfielder will now serve a three-match suspension, but only for non-first team fixtures.
Wilshere also appeared to take exception to an online report of the incident, which said his career had "hit a new low".
The Arsenal player wrote to the reporter on Twitter: " Evening Sam.Intrigued to hear more about how you think this is a career low for me? Would love a sit down with you? Look forward to it."
Having made his breaking through when aged just 16, Wilshere remains Arsenal's youngest player to have represented the club in the league, FA Cup and Europe , but appears to have fallen down the midfield pecking order behind the likes of Francis Coquelin and Granit Xhaka.
Speaking in August, Gunners boss Arsene Wenger made it clear Wilshere, who is in the final season of his current deal, remains in his plans, if the midfielder can return to full match fitness once again.
''At the moment, yes. I think I plan for him to be here for the whole season, after that we will see at the end of the season,'' Wenger said.
''He has the talent to be regular, but he has to come back to competition in a consistent way.''